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抑制性神经递质γ-氨基丁酸和甘氨酸的作用可能会区分猫的中央区和周边视网膜。

The action of inhibitory neurotransmitters, gamma-aminobutyric acid and glycine may distinguish between the area centralis and the peripheral retina in cats.

作者信息

Priest T D, Robbins J, Ikeda H

出版信息

Vision Res. 1985;25(12):1761-70. doi: 10.1016/0042-6989(85)90001-x.

DOI:10.1016/0042-6989(85)90001-x
PMID:3832602
Abstract

The effects of iontophoretically applied gamma-aminobutyric acid (GABA) and glycine, and of their antagonists, bicuculline and strychnine, were compared between ganglion cells from the central and peripheral retinae of optically intact eyes in barbiturate-anaesthetised cats. The visual response of on-cells was inhibited by GABA and enhanced by bicuculline. The visual response of off-cells was inhibited by glycine and enhanced by strychnine. The sensitivity of cells to the transmitters was lower in the peripheral retina than in the area centralis, whilst the sensitivity to the antagonists was similar in both regions of the retina. Cells from the area centralis were inhibited by either GABA or glycine, but never both. Cells from the periphery were less selective and were inhibited by both transmitters.

摘要

在巴比妥类麻醉的猫中,比较了离子电渗法施加的γ-氨基丁酸(GABA)和甘氨酸及其拮抗剂荷包牡丹碱和士的宁对视力正常眼睛中央和周边视网膜神经节细胞的影响。开细胞的视觉反应被GABA抑制,被荷包牡丹碱增强。关细胞的视觉反应被甘氨酸抑制,被士的宁增强。周边视网膜细胞对递质的敏感性低于中央凹区域,而视网膜两个区域对拮抗剂的敏感性相似。中央凹区域的细胞被GABA或甘氨酸抑制,但不会同时被两者抑制。周边的细胞选择性较低,被两种递质都抑制。

相似文献

1
The action of inhibitory neurotransmitters, gamma-aminobutyric acid and glycine may distinguish between the area centralis and the peripheral retina in cats.抑制性神经递质γ-氨基丁酸和甘氨酸的作用可能会区分猫的中央区和周边视网膜。
Vision Res. 1985;25(12):1761-70. doi: 10.1016/0042-6989(85)90001-x.
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Postnatal development of GABA- and glycine-mediated inhibition of feline retinal ganglion cells in the area centralis.猫中央凹区域视网膜神经节细胞中γ-氨基丁酸(GABA)和甘氨酸介导的抑制作用的产后发育
Brain Res. 1985 Nov;355(1):1-17. doi: 10.1016/0165-3806(85)90002-1.
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Functional transmitters at retinal ganglion cells in the cat.猫视网膜神经节细胞中的功能性递质。
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Action and localization of gamma-aminobutyric acid in the cat retina.γ-氨基丁酸在猫视网膜中的作用及定位
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Transmitters mediating inhibition of ganglion cells in the cat retina: iontophoretic studies in vivo.介导猫视网膜神经节细胞抑制作用的递质:体内离子电泳研究
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Action and localisation of neurotransmitters in the cat retina.神经递质在猫视网膜中的作用与定位。
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Actions of GABAergic ligands on brisk ganglion cells in the cat retina.γ-氨基丁酸能配体对猫视网膜中快适应性神经节细胞的作用。
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Effect of gamma-aminobutyric acid agonists, glycine, taurine and neuropeptides on acetylcholine release from the rabbit retina.γ-氨基丁酸激动剂、甘氨酸、牛磺酸和神经肽对兔视网膜乙酰胆碱释放的影响。
J Physiol. 1983 Mar;336:563-77. doi: 10.1113/jphysiol.1983.sp014598.

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GABAergic neurotransmission and retinal ganglion cell function.γ-氨基丁酸能神经传递与视网膜神经节细胞功能。
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015 Mar;201(3):261-83. doi: 10.1007/s00359-015-0981-z. Epub 2015 Feb 6.
2
Development of neurochemical separation of ON and OFF channels at retinal ganglion cells.视网膜神经节细胞上ON和OFF通道神经化学分离的发展。
Doc Ophthalmol. 1988 Jun;69(2):175-86. doi: 10.1007/BF00153699.