感染1型脊髓灰质炎病毒的恒河猴不同来源淋巴组织中的染色体畸变及免疫反应性
Chromosome aberrations in lymphoid tissues of different origin and immune responsiveness of Macaca rhesus monkeys infected with poliovirus type 1.
作者信息
Ilyinskikh I N, Ilyinskikh N
出版信息
Acta Virol. 1983 Sep;27(5):393-9.
A virulent strain of poliovirus type 1 induced aberrations in the chromosomal apparatus of both blood lymphocytes and bone marrow cells in infected Macaca rhesus monkeys. In addition, there were significant differences in the type and degree of aberrations, occurring in bone marrow cells and blood lymphocytes. Changes were also observed in the mitotic activity of bone marrow cells. Poliovirus inhibited the lymphocyte blast transformation (LBT) to phytohaemagglutinin (PHA), but enhanced the LBT to virus-specific antigen and the reactivity of neutrophils.
1型脊髓灰质炎病毒的一种强毒株在受感染的恒河猴体内引起了血液淋巴细胞和骨髓细胞染色体机构的畸变。此外，骨髓细胞和血液淋巴细胞中出现的畸变类型和程度存在显著差异。在骨髓细胞的有丝分裂活性方面也观察到了变化。脊髓灰质炎病毒抑制淋巴细胞对植物血凝素（PHA）的增殖转化（LBT），但增强了淋巴细胞对病毒特异性抗原的增殖转化以及中性粒细胞的反应性。
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