Bove A A, Dewey J D
Am J Cardiol. 1983 Dec 1;52(10):1333-9. doi: 10.1016/0002-9149(83)90597-0.
The effect of several vasoactive agents on epicardial conductance arteries and distal resistance arteries was studied in intact dogs using a special catheter system to infuse vasoactive mediators directly into the left anterior descending coronary artery of intact dogs. Serotonin produced significant epicardial vasoconstriction (42% cross-sectional area reduction, p less than 0.01), whereas histamine had no effect on proximal coronary arteries. Phenylephrine, an alpha-adrenergic agonist, produced an 11% reduction in cross-sectional area. Distal coronary vascular resistance (pressure/flow) changes were small for serotonin and phenylephrine, whereas histamine significantly dilated the peripheral vascular bed and caused flow measured by xenon-133 washout to increase from 30.4 +/- 4.0 to 72.4 +/- 12.6 ml/min . 100 g (p less than 0.05). These results show that vasoactive mediators can have different actions on coronary resistance and conductance vessels. Serotonin is a potent vasoconstrictor of epicardial coronary arteries but does not produce significant constriction of coronary resistance vessels.
使用一种特殊的导管系统，将血管活性介质直接注入完整犬的左前降支冠状动脉，研究了几种血管活性药物对心外膜传导动脉和远端阻力动脉的作用。5-羟色胺可引起显著的心外膜血管收缩（横截面积减少42%，p<0.01），而组胺对近端冠状动脉无作用。α-肾上腺素能激动剂去氧肾上腺素使横截面积减少11%。5-羟色胺和去氧肾上腺素引起的远端冠状动脉血管阻力（压力/流量）变化较小，而组胺可使外周血管床显著扩张，导致用氙-133洗脱法测得的血流量从30.4±4.0增加至72.4±12.6 ml/min·100 g（p<0.05）。这些结果表明，血管活性介质对冠状动脉阻力血管和传导血管可产生不同作用。5-羟色胺是心外膜冠状动脉的强效血管收缩剂，但对冠状动脉阻力血管无显著收缩作用。
