Ottesen B, Wagner G, Virag R, Fahrenkrug J
Br Med J (Clin Res Ed). 1984 Jan 7;288(6410):9-11. doi: 10.1136/bmj.288.6410.9.
Concentrations of vasoactive intestinal polypeptide were measured in blood drawn from the cavernous spaces of corpus cavernosum of the human penis during tumescence and erection, and the effect of injecting the polypeptide into the cavernous spaces was studied. A significant release of the polypeptide was shown during tumescence and erection. Injection of exogenous vasoactive intestinal polypeptide induced erection. These findings support the concept of vasoactive intestinal polypeptide as a neurotransmitter in penile erection and suggest that it might have a clinical use in patients suffering from erectile dysfunction.
在阴茎勃起和肿胀期间，测量了从人类阴茎海绵体的海绵间隙抽取的血液中血管活性肠肽的浓度，并研究了将该多肽注射到海绵间隙中的效果。结果显示，在勃起和肿胀期间该多肽有显著释放。注射外源性血管活性肠肽可诱导勃起。这些发现支持了血管活性肠肽作为阴茎勃起神经递质的概念，并表明它可能对患有勃起功能障碍的患者具有临床应用价值。
