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Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O-methyltransferase.

作者信息

Cremer-Bartels G, Ebels I, Sykes J E, de Morée A

出版信息

J Neural Transm. 1983;58(1-2):107-19. doi: 10.1007/BF01249129.

DOI:10.1007/BF01249129
PMID:6140301
Abstract

Fractions from bovine retinas and sheep pineals of low molecular weight decrease the activity of purified hydroxyindole-O-methyltransferase (HIOMT). The antipsychotic drugs chlorpromazine and haloperidol show a similar effect under the same experimental conditions. It is suggested that they may imitate the effect of (an) unknown natural suppressor(s) of HIOMT-activity, present in retina and pineal, decreasing the biosynthesis of methoxyindoles.

摘要

相似文献

1
Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O-methyltransferase.
J Neural Transm. 1983;58(1-2):107-19. doi: 10.1007/BF01249129.
2
Inhibition of avian and mammalian hydroxy-indole-o-methyl-transferase (HIOMT) with low molecular weight fractions of mammalian pineal glands.
Life Sci. 1982 Apr 19;30(16):1369-77. doi: 10.1016/0024-3205(82)90022-4.
3
An antiserum against chicken hydroxyindole-O-methyltransferase reacts with the enzyme from pineal gland and retina and labels pineal modified photoreceptors.一种抗鸡羟基吲哚-O-甲基转移酶的抗血清与来自松果体和视网膜的该酶发生反应，并标记松果体中经过修饰的光感受器。
Brain Res. 1988 Aug;464(1):53-61. doi: 10.1016/0169-328x(88)90018-6.
4
The effect of pteridines on multiple forms of hydroxyindole-O-methyltransferase (HIOMT) in the retina and the pineal gland.蝶啶对视网膜和松果体中多种形式的羟基吲哚 - O - 甲基转移酶（HIOMT）的影响。
Prog Brain Res. 1979;52:231-9. doi: 10.1016/S0079-6123(08)62926-X.
5
Localization of hydroxyindole-O-methyltransferase in the mammalian pineal gland and retina.羟吲哚-O-甲基转移酶在哺乳动物松果体和视网膜中的定位。
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6
Inhibition of the catalytic activity of bovine pineal gland hydroxyindole-O-methyltransferase (EC 2.1.1.4) by estrone, estradiol, progesterone, and testosterone but not pteridines.雌酮、雌二醇、孕酮和睾酮对牛松果体羟吲哚-O-甲基转移酶（EC 2.1.1.4）催化活性具有抑制作用，而蝶啶则无此作用。
J Pineal Res. 1989;6(3):259-65. doi: 10.1111/j.1600-079x.1989.tb00422.x.
7
Immunocytochemical demonstration of hydroxyindole O-methyltransferase (HIOMT), neuron-specific enolase (NSE) and S-100 protein in the bovine pineal gland.牛松果体中羟吲哚-O-甲基转移酶（HIOMT）、神经元特异性烯醇化酶（NSE）和S-100蛋白的免疫细胞化学显示
Brain Res. 1983 Sep 5;274(1):171-5. doi: 10.1016/0006-8993(83)90535-8.
8
Species heterogeneity of pineal hydroxyindole-O-methyltransferase.松果体羟吲哚-O-甲基转移酶的物种异质性
J Neurochem. 1983 Mar;40(3):790-6. doi: 10.1111/j.1471-4159.1983.tb08048.x.
9
Mechanism of inhibition of bovine pineal gland hydroxyindole-O-methyltransferase (EC 2.1.1.4) by divalent cations.
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10
Pteridines as nonretinal regulators of light-dependent melatonin biosynthesis.蝶啶作为光依赖性褪黑素生物合成的非视网膜调节因子。
Proc Natl Acad Sci U S A. 1980 May;77(5):2415-8. doi: 10.1073/pnas.77.5.2415.

引用本文的文献

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本文引用的文献

1
Drugs, neurotransmitters, and schizophrenia.药物、神经递质与精神分裂症
Science. 1974 Jun 21;184(4143):1243-53. doi: 10.1126/science.184.4143.1243.
2
MELATONIN SYNTHESIS IN THE PINEAL GLAND: CONTROL BY LIGHT.松果体中的褪黑素合成：受光控制。
Science. 1963 Nov 22;142(3595):1071-3. doi: 10.1126/science.142.3595.1071.
3
Human post-mortem pineal enzyme activity.人类松果体尸检酶活性。
Clin Endocrinol (Oxf). 1981 Jan;14(1):75-81. doi: 10.1111/j.1365-2265.1981.tb00367.x.
4
Inhibition of avian and mammalian hydroxy-indole-o-methyl-transferase (HIOMT) with low molecular weight fractions of mammalian pineal glands.
Life Sci. 1982 Apr 19;30(16):1369-77. doi: 10.1016/0024-3205(82)90022-4.
5
Pteridines as nonretinal regulators of light-dependent melatonin biosynthesis.蝶啶作为光依赖性褪黑素生物合成的非视网膜调节因子。
Proc Natl Acad Sci U S A. 1980 May;77(5):2415-8. doi: 10.1073/pnas.77.5.2415.
6
[Effect of chlorpromazine on biosynthesis of melatonin in the retina].[氯丙嗪对视网膜中褪黑素生物合成的影响]
Fortschr Ophthalmol. 1983;79(5):470-2.
7
The distribution of haloperidol in rat brain.氟哌啶醇在大鼠脑中的分布。
Br J Pharmacol. 1969 May;36(1):208P-209P.
8
Localization of a sheep pineal antigonadotropin.
Anal Biochem. 1973 Dec;56(2):546-65. doi: 10.1016/0003-2697(73)90220-0.
9
The inhibition of pineal hydroxyindole-O-methyltransferase by haloperidol and fluphenazine.氟哌啶醇和氟奋乃静对松果体羟吲哚-O-甲基转移酶的抑制作用。
J Pharm Pharmacol. 1972 Dec;24:Suppl:100P-103.
10
Separation of pineal extracts by gelfiltration. IV. Isolation, location and identification from sheep pineals of three indoles, identical with 5-hydroxytryptophol, 5-methoxytryptophol and melatonin.通过凝胶过滤法分离松果体提取物。IV. 从绵羊松果体中分离、定位和鉴定三种吲哚，它们与5-羟色醇、5-甲氧基色醇和褪黑素相同。
J Neural Transm. 1976;38(1):31-41. doi: 10.1007/BF01254138.