Curtis H M, Leck I, Bamford F N
Lancet. 1984 Jan 21;1(8369):145-8. doi: 10.1016/s0140-6736(84)90072-2.
Neonatal BCG vaccination has long been offered routinely to children born at St Mary's Hospital (SMH), Manchester, England, whereas the city's other obstetric hospitals have generally restricted this procedure to children of Asian origin and those with a family history of tuberculosis. Among children aged 0-14 years who had been born to Manchester residents in 1965-80, 65 presented with tuberculosis in 1975-80 whilst still resident in the city. The estimated incidence rate was less than half as high among all children born at SMH as among those not born there, largely because the rate for those born and vaccinated at SMH was less than one-quarter of that for those born elsewhere. Children with Bangladeshi, Indian, or Pakistani surnames also shared in the reduced risk associated with vaccination. These findings strongly support the effectiveness of neonatal BCG vaccination.
长期以来，英国曼彻斯特圣玛丽医院（SMH）一直对在该院出生的儿童常规接种新生儿卡介苗，而该市其他产科医院通常仅对亚裔儿童以及有结核病家族史的儿童进行此项接种。在1965年至1980年间出生于曼彻斯特的0至14岁儿童中，有65人在1975年至1980年间仍居住在该市时患了结核病。据估计，在SMH出生的所有儿童中的发病率不到未在该院出生儿童发病率的一半，这主要是因为在SMH出生并接种疫苗的儿童发病率不到在其他地方出生儿童发病率的四分之一。姓氏为孟加拉、印度或巴基斯坦的儿童也因接种疫苗而降低了患病风险。这些发现有力地支持了新生儿卡介苗接种的有效性。
