Takagi M, Ikeda T, Kimura K, Saito Y, Ishii M, Takeda T, Murao S
Nephron. 1984;36(1):68-73. doi: 10.1159/000183118.
Clinical findings and structural alterations of the kidney in 3 patients with Takayasu's arteritis (TA) and associated glomerulonephritis are described. Clinical evidence of renal disease included persistent proteinuria and microscopic hematuria in all patients. Renal histology showed proliferative glomerulonephritis in 2 of the 3 patients. In 1 patient in whom sequential examination of the kidney was possible, glomerular changes had progressed in severity, in parallel with the expansion of arterial damage of TA. Prednisolone therapy induced a complete disappearance of systemic symptoms of TA and an improvement of proteinuria and hematuria. These findings suggest that TA, which quite possibly results from an immune response to disseminated antigen(s), may occasionally induced glomerulonephritis as a part of its histological expression.
描述了3例大动脉炎（TA）合并肾小球肾炎患者的临床发现及肾脏结构改变。肾脏疾病的临床证据包括所有患者均有持续性蛋白尿和镜下血尿。肾脏组织学检查显示，3例患者中有2例为增殖性肾小球肾炎。在1例可以对肾脏进行连续检查的患者中，肾小球病变的严重程度随着TA动脉损伤范围的扩大而进展。泼尼松龙治疗使TA的全身症状完全消失，蛋白尿和血尿有所改善。这些发现提示，TA很可能是由对播散性抗原的免疫反应引起的，偶尔可能会诱发肾小球肾炎作为其组织学表现的一部分。
