Lai K N, Chan K W, Ho C P
Am J Kidney Dis. 1986 Mar;7(3):197-204. doi: 10.1016/s0272-6386(86)80003-8.
Clinical features and pathologic findings of the kidney in three patients with Takayasu's arteritis and associated nephritis are described. Clinical evidence of renal disease included proteinuria, hematuria, and a reduction of glomerular filtration rate. Renal histology revealed mesangial proliferative glomerulonephritis in one patient and minor glomerular abnormalities in the other two. The clinical course of the glomerulopathy is slow, yet progressive, and the corticosteroid and immunosuppressive therapy appear to delay the progression of the glomerular damage. In one patient in whom repeated examination of the kidney after corticosteroid and immunosuppressive treatment was possible, the glomerular pathology remained unchanged. This report of three patients with Takayasu's arteritis and concomitant nephritis supports the previous speculation of the association between these two conditions. The glomerular, vasculitic, and arteriopathic involvements in these patients may suggest a common immunologic mechanism.
本文描述了3例大动脉炎合并肾炎患者的肾脏临床特征和病理表现。肾脏疾病的临床证据包括蛋白尿、血尿和肾小球滤过率降低。肾脏组织学检查显示，1例患者为系膜增生性肾小球肾炎，另外2例患者有轻微的肾小球异常。肾小球病的临床病程缓慢，但呈进行性发展，糖皮质激素和免疫抑制治疗似乎可延缓肾小球损伤的进展。在1例患者中，糖皮质激素和免疫抑制治疗后能够反复检查肾脏，其肾小球病理改变未发生变化。本文对3例大动脉炎合并肾炎患者的报道支持了此前关于这两种疾病之间存在关联的推测。这些患者的肾小球、血管和动脉病变可能提示存在共同的免疫机制。
