Bean J R, Darling J L, Hoyle N R, Arigbabu S O, Thomas D G
Neurol Res. 1983;5(1):61-75. doi: 10.1080/01616412.1983.11739632.
Leucocyte migration inhibition in response to ubiquitous antigens was studied in 104 patients as an in vitro indicator of cell-mediated immunity. Patients with cerebral glioma, benign intracranial tumours, and subarachnoid haemorrhage demonstrated impaired inhibition of leucocyte migration compared with control subjects. The greatest impairment occurred in patients with subarachnoid haemorrhage, while the least impairment was seen in patients with glioma. Significant rises in inhibition of leucocyte migration in response to antigen preparations from glioma and normal brain were seen in the early post-operative period in patients with glioma and subarachnoid haemorrhage. Impaired cellular immunity, together with sensitivity of lymphocytes to brain-derived antigens, are features of cerebral disease in general and not specific for glioma.
作为细胞介导免疫的体外指标，对104例患者进行了针对普遍存在抗原的白细胞迁移抑制研究。与对照组相比，患有脑胶质瘤、颅内良性肿瘤和蛛网膜下腔出血的患者白细胞迁移抑制受损。蛛网膜下腔出血患者的损伤最为严重，而胶质瘤患者的损伤最小。胶质瘤和蛛网膜下腔出血患者在术后早期，对来自胶质瘤和正常脑组织的抗原制剂的白细胞迁移抑制有显著升高。细胞免疫受损以及淋巴细胞对脑源性抗原的敏感性是一般脑部疾病的特征，而非胶质瘤所特有。
