Influence of a continuous intragastric and intravenous infusion of somatostatin on stimulated gastric secretion.

Our study demonstrated that somatostatin given i.v. in a dose of 250 micrograms/kg per hour significantly inhibited pentagastrin-stimulated gastric secretion, whereas continuous intragastric administration of somatostatin (up to 3 mg/h) failed to do so. We concluded, therefore, that luminally secreted somatostatin plays only a minor role in the regulation of gastric secretion.