Kétyi I, Naumann G, Nimmich W
Acta Microbiol Hung. 1983;30(2):155-61.
The virulence factors of Escherichia coli supposed to act in urinary tract infections were studied on R strains in a suckling mouse model. The production of alpha-(diffusible-) haemolysin or the possession of antigen K1 enhanced the virulence significantly, while the type 1 (common) fimbriae failed to do so. An isogenic motile and non-motile pair of E. coli did not show any difference in infectivity in the model. The adhesins, the diffusible haemolysin, and the acidic polysaccharide K antigens (K1) are definitely additive virulence factors in the model. This is in good agreement with the experience of clinical bacteriology.
在乳鼠模型中，利用R菌株研究了推测在尿路感染中起作用的大肠杆菌毒力因子。α-（可扩散的）溶血素的产生或K1抗原的存在显著增强了毒力，而1型（普通）菌毛则没有。一对同基因的运动型和非运动型大肠杆菌在该模型中的感染性没有差异。在该模型中，黏附素、可扩散溶血素和酸性多糖K抗原（K1）无疑是累加性毒力因子。这与临床细菌学的经验高度一致。
