不同初始生物学特性的普氏立克次体在感染棉鼠体内的持续性

Persistence of Rickettsia prowazekii with different initial biological properties in infected cotton rats.

作者信息

Ignatovich V F, Barkhatova O I, Rydkina E B

出版信息

Acta Virol. 1983 Nov;27(6):528-32.

Abstract

Evidence has been obtained indicating the association of certain biological properties of Rickettsia prowazekii with their capacity for persistence. Highly virulent rickettsial cultures inducing increased levels of complement-fixing antibodies were shown to cause a high percentage of rickettsial carriers in infected cotton rats. Within an interval of 133-189 days after inoculation with the virulent Breinl strain, rickettsial carrier-state was still demonstrable in 20% of the animals. The vaccine strain E of R. prowazekii had a low capacity for persistence in cotton rats, because 64 days after inoculation all animals were found free of rickettsiae.

摘要

已获得的证据表明，普氏立克次体的某些生物学特性与其持续存在的能力相关。诱导补体结合抗体水平升高的高毒力立克次体培养物显示，在感染的棉鼠中会导致高比例的立克次体携带者。在用强毒布雷因尔菌株接种后的133-189天内，仍有20%的动物可检测到立克次体携带状态。普氏立克次体疫苗株E在棉鼠中的持续存在能力较低，因为接种64天后，所有动物均未检测到立克次体。