咪达唑仑术前用药后的抗利尿激素浓度。

Antidiuretic hormone concentrations following midazolam premedication.

作者信息

Sjovall S, Kanto J, Grönroos M, Himberg J J, Kangas L, Viinamäki O

出版信息

Anaesthesia. 1983 Dec;38(12):1217-20. doi: 10.1111/j.1365-2044.1983.tb12529.x.

DOI:10.1111/j.1365-2044.1983.tb12529.x

Abstract

Midazolam given orally the night before and on the morning of operation had a distinct subjective pre-operative sedative effect as compared with placebo. Patients receiving midazolam also experienced less apprehension and excitement before surgery, but in relation to quality of sleep, the difference between the two groups was not statistically significant. Antidiuretic hormone (ADH) concentrations were determined just before induction of anaesthesia and were significantly lower in the midazolam group (2.14 pg/ml, SD 0.96) than in the placebo group (3.07 pg/ml, SD 1.73). Our results show that midazolam is a useful sedative anxiolytic oral premedicant, which appears to prevent initiation of a stress reaction before induction of anaesthesia.

摘要

术前一晚及手术当天早晨口服咪达唑仑，与安慰剂相比，具有明显的术前主观镇静效果。接受咪达唑仑的患者在手术前也较少感到忧虑和兴奋，但就睡眠质量而言，两组之间的差异无统计学意义。在诱导麻醉前测定抗利尿激素（ADH）浓度，咪达唑仑组（2.14 pg/ml，标准差0.96）显著低于安慰剂组（3.07 pg/ml，标准差1.73）。我们的结果表明，咪达唑仑是一种有用的镇静抗焦虑口服术前用药，似乎可在诱导麻醉前防止应激反应的启动。