Kristiansen B E, Rustad L, Spanne O, Bjorvatn B
Antimicrob Agents Chemother. 1983 Nov;24(5):731-4. doi: 10.1128/AAC.24.5.731.
Neisseria meningitidis is known to be highly resistant to lincomycin (minimum inhibitory concentration greater than 32 micrograms/ml). However, during studies on meningococcal piliation, we noticed a significant reduction in the number of pili after cultivation on lincomycin-containing selective media. This observation was followed up by in vitro and in vivo studies on the relation between lincomycin and meningococcal adherence to human epithelial cells. We found a remarkable decrease in in vitro piliation and adherence after exposure to lincomycin at concentrations as low as 0.05 micrograms/ml. By giving four healthy meningococcal carriers lincomycin orally for 3 to 6 days, the possible in vivo effect of lincomycin was studied. A marked decrease in the meningococcal counts of the pharyngeal secretion was observed. One person completely lost his meningococcal strain during the observation period.
已知脑膜炎奈瑟菌对林可霉素具有高度耐药性（最低抑菌浓度大于32微克/毫升）。然而，在对脑膜炎球菌菌毛的研究过程中，我们注意到在含林可霉素的选择性培养基上培养后菌毛数量显著减少。随后针对林可霉素与脑膜炎球菌对人上皮细胞的黏附之间的关系进行了体外和体内研究。我们发现，暴露于低至0.05微克/毫升浓度的林可霉素后，体外菌毛形成和黏附能力显著下降。通过给四名健康的脑膜炎球菌携带者口服林可霉素3至6天，研究了林可霉素可能的体内作用。观察到咽部分泌物中脑膜炎球菌数量显著减少。在观察期内，有一人的脑膜炎球菌菌株完全消失。
