三唑并二氮䓬类药物三唑仑和溴替唑仑的疗效与耐受性比较研究
Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam.
作者信息
Goetzke E, Findeisen P, Welbers I B
出版信息
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):407S-412S. doi: 10.1111/j.1365-2125.1983.tb02318.x.
Abstract
Efficacy of and tolerance to 0.25 mg brotizolam and 0.25 mg triazolam were compared in hospitalised patients (aged 20 to 69 years) with sleep difficulties. Over 6 days there were no differences in efficacy and tolerance. The physicians reported the effectiveness of the drugs as good-to-satisfactory in 88.6% with brotizolam and 92.0% with triazolam. The patients reported with both drugs reduced time to fall asleep, less awakenings, increased duration of sleep and improved condition on awakening.
摘要
对有睡眠困难的住院患者（年龄在20至69岁之间）比较了0.25毫克溴替唑仑和0.25毫克三唑仑的疗效及耐受性。在6天的时间里，二者在疗效和耐受性方面没有差异。医生报告称，使用溴替唑仑的患者中88.6%的药物有效性良好至令人满意，使用三唑仑的患者中这一比例为92.0%。患者报告称，使用这两种药物后入睡时间缩短、觉醒次数减少、睡眠时间延长且醒来时状况有所改善。
相似文献
1
Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam.三唑并二氮䓬类药物三唑仑和溴替唑仑的疗效与耐受性比较研究
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):407S-412S. doi: 10.1111/j.1365-2125.1983.tb02318.x.
2
Comparative studies on the efficacy of brotizolam and nitrazepam: a multi-centre study.溴替唑仑与硝西泮疗效的比较研究：一项多中心研究。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):403S-406S. doi: 10.1111/j.1365-2125.1983.tb02317.x.
3
Efficacy and tolerance: comparative studies with brotizolam and flunitrazepam.疗效与耐受性：溴替唑仑与氟硝西泮的对比研究。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):397S-401S. doi: 10.1111/j.1365-2125.1983.tb02316.x.
4
Efficacy and acceptability of brotizolam in the elderly.溴替唑仑在老年人中的疗效与可接受性。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):391S-395S. doi: 10.1111/j.1365-2125.1983.tb02315.x.
5
Changes of cyclic alternating pattern (CAP) parameters in situational insomnia under brotizolam and triazolam.在使用溴替唑仑和三唑仑治疗情境性失眠时循环交替模式（CAP）参数的变化
Psychopharmacology (Berl). 1995 Aug;120(3):237-43. doi: 10.1007/BF02311169.
6
Brotizolam as a pre-operative hypnotic.溴替唑仑作为术前催眠药。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):419S-423S. doi: 10.1111/j.1365-2125.1983.tb02322.x.
7
Tolerance studies with brotizolam in hospitalized patients.住院患者中溴替唑仑的耐受性研究。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):385S-389S. doi: 10.1111/j.1365-2125.1983.tb02314.x.
8
A double-blind comparison of two benzodiazepine hypnotics, flunitrazepam and triazolam, in general practice.在普通医疗实践中对两种苯二氮䓬类催眠药氟硝西泮和三唑仑进行的双盲比较。
Curr Med Res Opin. 1984;8(10):714-9. doi: 10.1185/03007998409110122.
9
Midazolam and triazolam in out-patients: a double-blind comparison of hypnotic efficacy.门诊患者使用咪达唑仑和三唑仑：催眠疗效的双盲对比
Br J Clin Pharmacol. 1983;16 Suppl 1(Suppl 1):179S-183S. doi: 10.1111/j.1365-2125.1983.tb02292.x.
10
Brotizolam and chronic insomnia: a multi-centre study.溴替唑仑与慢性失眠：一项多中心研究。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):413S-414S. doi: 10.1111/j.1365-2125.1983.tb02319.x.
引用本文的文献
1
Pharmacological interventions to improve sleep in hospitalised adults: a systematic review.改善住院成人睡眠的药物干预措施：一项系统评价
BMJ Open. 2016 Jul 29;6(7):e012108. doi: 10.1136/bmjopen-2016-012108.
2
Meta-analysis of benzodiazepine use in the treatment of insomnia.苯二氮䓬类药物用于治疗失眠的荟萃分析。
CMAJ. 2000 Jan 25;162(2):225-33.
3
Brotizolam. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as an hypnotic.溴替唑仑。对其药效学和药代动力学特性以及作为催眠药的治疗效果的综述。
Drugs. 1988 Feb;35(2):104-22. doi: 10.2165/00003495-198835020-00002.
本文引用的文献
1
Diazepam disposition determinants.地西泮处置的决定因素。
Clin Pharmacol Ther. 1980 Mar;27(3):301-12. doi: 10.1038/clpt.1980.40.
2
Effect of a new thienodiazepine (We-941) on sleep patterns of normal and insomniac subjects.一种新型噻吩二氮䓬（We-941）对正常受试者和失眠受试者睡眠模式的影响。
Neuropharmacology. 1981 May;20(5):461-8. doi: 10.1016/0028-3908(81)90178-7.
3
Pharmacokinetics and metabolism of brotizolam in animals.溴替唑仑在动物体内的药代动力学与代谢
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):261S-266S. doi: 10.1111/j.1365-2125.1983.tb02298.x.
4
Brotizolam as a pre-operative hypnotic.溴替唑仑作为术前催眠药。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):419S-423S. doi: 10.1111/j.1365-2125.1983.tb02322.x.
5
Efficacy and tolerance: comparative studies with brotizolam and flunitrazepam.疗效与耐受性：溴替唑仑与氟硝西泮的对比研究。
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):397S-401S. doi: 10.1111/j.1365-2125.1983.tb02316.x.
6
Comparative pharmacokinetics of brotizolam and triazolam in healthy subjects.健康受试者中溴替唑仑和三唑仑的比较药代动力学
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):291S-297S. doi: 10.1111/j.1365-2125.1983.tb02303.x.
7
Pharmacology and hypnogenic properties of brotizolam in animals.溴替唑仑在动物体内的药理学及催眠特性
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):253S-260S. doi: 10.1111/j.1365-2125.1983.tb02297.x.
8
Triazolam disposition.
Clin Pharmacol Ther. 1981 Jan;29(1):81-93. doi: 10.1038/clpt.1981.14.
Zotero 插件