溴替唑仑在老年人中的疗效与可接受性。
Efficacy and acceptability of brotizolam in the elderly.
作者信息
von Delbrück O, Nagel C, Lichterfeld A
出版信息
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):391S-395S. doi: 10.1111/j.1365-2125.1983.tb02315.x.
Efficacy of and tolerance to brotizolam were studied over 6 days in elderly patients (62 to 93 years) suffering from sleep disturbance requiring medication: 62.9% used 0.125 mg and 32.0% used 0.25 mg. Effectiveness of brotizolam was assessed as good-to-satisfactory in 87.1% of the patients. Efficacy of and tolerance to brotizolam were compared with nitrazepam in mainly elderly patients (56-91 years) with sleep disturbances requiring medication. Efficacy was assessed as good-to-satisfactory in 89.8% of patients with 0.125 mg brotizolam, 93.9% with 0.25 mg brotizolam and 95.9% with 5 mg nitrazepam. Patients reported improved sleep with all three preparations. The dose range of brotizolam recommended for the elderly is 0.125-0.25 mg, though for the vast majority of patients the lower dose will be sufficient.
对患有睡眠障碍且需要药物治疗的老年患者（62至93岁）进行了为期6天的溴替唑仑疗效及耐受性研究：62.9%的患者使用0.125毫克，32.0%的患者使用0.25毫克。87.1%的患者评估溴替唑仑的有效性为良好至满意。在主要患有睡眠障碍且需要药物治疗的老年患者（56 - 91岁）中，将溴替唑仑的疗效及耐受性与硝西泮进行了比较。使用0.125毫克溴替唑仑的患者中，89.8%的患者疗效评估为良好至满意，使用0.25毫克溴替唑仑的患者为93.9%，使用5毫克硝西泮的患者为95.9%。患者报告使用这三种制剂后睡眠均有改善。推荐给老年人的溴替唑仑剂量范围是0.125 - 0.25毫克，不过对绝大多数患者来说，较低剂量就足够了。
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