Netti C, Guidobono F, Sibilia V, Olgiati V R, Pagani F, Pecile A
Horm Res. 1984;19(1):12-7. doi: 10.1159/000179854.
We attempted to determine whether the suppression by histamine of spontaneous episodic growth hormone (GH) secretion is mediated by an augmented release of somatostatin (SS). Adult male rats were passively immunized against SS by the injection of a specific goat anti-SS antibody. Plasma GH levels in rats bearing indwelling catheters were measured at 15-min intervals for 4 h. Histamine (0.1 mumol/rat) was administered intracerebroventricularly (i.c.v.) 1 h after the start of the experiment and once an hour for the next 2 h. Anti-SS serum (2 ml) was injected 2 h after the beginning of the experiment to two groups of rats, one given saline i.c.v. and the other histamine i.c.v. Histamine was able to suppress not only spontaneous GH secretion but also the antiserum-stimulated GH release. These data suggest that histamine inhibiton of GH is not mediated by SS but probably by a reduction of GH-releasing hormone or some other stimulatory signal.
我们试图确定组胺对自发性阵发性生长激素（GH）分泌的抑制作用是否由生长抑素（SS）释放增加介导。成年雄性大鼠通过注射特异性山羊抗SS抗体进行被动免疫以对抗SS。对留置导管的大鼠，每隔15分钟测量一次血浆GH水平，持续4小时。实验开始1小时后，通过脑室内注射（i.c.v.）给予组胺（0.1μmol/大鼠），并在接下来的2小时内每小时注射一次。实验开始2小时后，向两组大鼠注射抗SS血清（2ml），一组脑室内注射生理盐水，另一组脑室内注射组胺。组胺不仅能够抑制自发性GH分泌，还能抑制抗血清刺激的GH释放。这些数据表明，组胺对GH的抑制作用不是由SS介导的，可能是通过减少生长激素释放激素或其他一些刺激信号来实现的。
