Meyer S, Landau H
J Pediatr Orthop. 1984 Jan;4(1):28-31. doi: 10.1097/01241398-198401000-00007.
Of a group of 79 patients (45 males, 34 females) with myelomeningocele (MMC), 52 had associated hydrocephalus. Three of the hydrocephalic patients (two arrested and one shunted) were found to have precocious sexual development. Endocrine investigations confirmed true isosexual precocity. Hydrocephalus is known to be associated with precocious puberty, but the occurrence of sexual precocity in patients with hydrocephalus in conjunction with MMC has not been described to date. As the clinical diagnosis of hydrocephalus in a young child is often unreliable, routine computerized tomographic scans of all MMC patients is advised, and even patients with arrested hydrocephalus should be followed carefully for signs of precocious puberty. In addition, a high incidence (15%) of cryptorchidism was found in the group of MMC patients reviewed.
在一组79例脊髓脊膜膨出（MMC）患者（45例男性，34例女性）中，52例伴有脑积水。在脑积水患者中有3例（2例未治疗，1例分流治疗）出现性早熟。内分泌检查证实为真性同性性早熟。脑积水已知与性早熟有关，但脑积水合并MMC患者出现性早熟的情况迄今尚未见报道。由于幼儿脑积水的临床诊断往往不可靠，建议对所有MMC患者进行常规计算机断层扫描，即使是脑积水病情稳定的患者也应密切随访观察性早熟迹象。此外，在所回顾的MMC患者组中发现隐睾症的发生率很高（15%）。
