Brauner R, Rappaport R, Nicod C, Malandry F, Thibaud E, Pierre-Kahn A, Renier D, Sainte-Rose C, Hirsch J F
Arch Fr Pediatr. 1987 Jun-Jul;44(6):433-6.
True precocious puberty occurred in 16 children (15 girls and 1 boy) with non tumoral shunted hydrocephalus at a mean age of 6.8 years. They had mild clinical manifestations of precocious puberty, and the other pituitary functions were found to be normal. Except for one child, precocious puberty did not correlate with raised intracranial pressure or lack of cerebral drainage by the shunt. Growth was the main concern in this group as the predicted height fell at a mean value of 1.7 SD below the parental target height, and even more in children with myelomeningocele. This growth retardation is due to an early progression of bone age observed even prior to the appearance of breast or pubic hair. Therefore we suggest that these children might benefit from early treatment by an LHRH analogue as soon as precocious puberty occurs.
16名患有非肿瘤性分流性脑积水的儿童（15名女孩和1名男孩）出现真性性早熟，平均年龄为6.8岁。他们有轻度性早熟的临床表现，且发现其他垂体功能正常。除1名儿童外，性早熟与颅内压升高或分流器引流不畅无关。生长是该组主要关注的问题，因为预测身高平均比父母目标身高低1.7标准差，脊髓脊膜膨出患儿的差距更大。这种生长迟缓是由于在乳房或阴毛出现之前就观察到骨龄提前进展。因此，我们建议这些儿童一旦出现性早熟，尽早使用促性腺激素释放激素类似物进行治疗可能会受益。
