Stupfel M, Halberg F, Mordelet-Dambrine M, Magnier M
Chronobiologia. 1977 Oct-Dec;4(4):333-51.
In a series of experiments, male and female Sprague Dawley rats, kept in light (L) from 06(00) to 18(00) alternating with darkness (LD 12:12) inhaled different concentrations of carbon monoxide (50-1,700 ppm) at each of two test times, 12 h apart. A decrease in flow of CO2 (VCO2) resulting from CO inhalation was greater in the active dark (D) than resting light (L) span. Experimental hypoxic mortality of male and female mice also shows circadian variations, being greater in the D than in the L span. Moreover, a difference of mortality was observed betwen hypoxic exposures performed at 12(00) (in LD or DL) and hypoxic exposures performed at 00(00) (in LD or DL). Such results await tests of any extent to which they model responses of human beings to air pollution. In human beings any external environmental circadian, circaseptan and circannual variations in air pollution as such may serve to variable extent as socioeconomic synchronizers of innate rhythms with a corresponding frequency, rather than as solely generators of time patterns in any physiopathologic response to air pollution.
在一系列实验中，将雄性和雌性斯普拉格-道利大鼠饲养在光照（L）时间为06(00)至18(00)、与黑暗（LD 12:12）交替的环境中，在两个测试时间（相隔12小时）分别吸入不同浓度的一氧化碳（50 - 1700 ppm）。吸入一氧化碳导致的二氧化碳流量（VCO2）下降在活跃的黑暗（D）时段比休息的光照（L）时段更大。雄性和雌性小鼠的实验性缺氧死亡率也表现出昼夜节律变化，在D时段比在L时段更高。此外，观察到在12(00)（在LD或DL条件下）进行的缺氧暴露与在00(00)（在LD或DL条件下）进行的缺氧暴露之间的死亡率差异。这些结果有待测试它们在多大程度上模拟人类对空气污染的反应。在人类中，空气污染本身的任何外部环境昼夜、近一周和近一年变化可能在不同程度上作为具有相应频率的先天节律的社会经济同步器，而不是在对空气污染的任何病理生理反应中仅仅作为时间模式的产生者。
