Yovich J L, Stanger J D, Kay D, Boettcher B
Lancet. 1984 Feb 18;1(8373):369-70. doi: 10.1016/s0140-6736(84)90415-x.
Five women whose infertility was believed to be related primarily to their serum antisperm antibodies underwent in-vitro fertilisation and embryo transfer. Follicle growth was stimulated with clomiphene citrate, sometimes combined with human menopausal gonadotropin, and ovulation was triggered off with human chorionic gonadotropin. 20 oocytes were collected from the five patients, and 15 of these were fertilised in the presence of donor serum. All embryos developed to morphologically normal 2-cell and 4-cell embryos. All five women proceeded to embryo transfer, and two became pregnant.
五名被认为不孕主要与血清抗精子抗体有关的女性接受了体外受精和胚胎移植。使用枸橼酸氯米芬刺激卵泡生长，有时联合人绝经期促性腺激素，并用绒毛膜促性腺激素触发排卵。从这五名患者中采集了20个卵母细胞，其中15个在供体血清存在的情况下受精。所有胚胎均发育为形态正常的2细胞和4细胞胚胎。所有五名女性都进行了胚胎移植，其中两名怀孕。
