Pilkington G J, Smith D A, Lantos P L
Neurosci Lett. 1983 Dec 2;42(2):213-8. doi: 10.1016/0304-3940(83)90409-3.
A cell clone, isolated from normal adult rat brain and maintained in culture for many passages, has been previously characterized by electron microscopy. Immunohistochemistry has now been shown that it possesses glutamine synthetase (GS) which supports its astrocytic origin. Cells failed, however, to express glial fibrillary acidic protein (GFAP) but did express the intermediate filament protein vimentin. The presence of fibronectin confirms the normal derivation of these cells and excludes the possibility of malignant transformation.
一个从正常成年大鼠大脑中分离出来并在培养中传代多次的细胞克隆，此前已通过电子显微镜进行了表征。现在免疫组织化学显示它具有谷氨酰胺合成酶（GS），这支持了其星形胶质细胞起源。然而，这些细胞未能表达胶质纤维酸性蛋白（GFAP），但确实表达了中间丝蛋白波形蛋白。纤连蛋白的存在证实了这些细胞的正常来源，并排除了恶性转化的可能性。
