来自化学诱导大鼠胶质瘤的克隆性肿瘤细胞：免疫细胞化学特征分析
Cloned neoplastic cells from a chemically-induced rat glioma: immunocytochemical characterization.
作者信息
Pilkington G J, Martin J M, Lantos P L
出版信息
Br J Exp Pathol. 1985 Oct;66(5):561-6.
Abstract
A cell clone--A15 A5--derived from an N-ethyl-N-nitrosourea (ENU)-induced glioma in a BDIX rat has been maintained in vitro for over 50 passages. These cells, which produce tumours when injected intracerebrally into syngeneic rats, possess several features of neoplastic astrocytes. In the present study A15 A5 cells were found to express both glial fibrillary acidic protein and glutamine synthetase, thus confirming their astrocytic nature.
摘要
从一只BDIX大鼠经N-乙基-N-亚硝基脲（ENU）诱导产生的胶质瘤中分离出的细胞克隆A15 A5，已在体外传代培养50多次。将这些细胞脑内注射到同基因大鼠体内时会产生肿瘤，它们具有肿瘤性星形胶质细胞的若干特征。在本研究中，发现A15 A5细胞同时表达胶质纤维酸性蛋白和谷氨酰胺合成酶，从而证实了它们的星形胶质细胞性质。
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