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来自化学诱导大鼠胶质瘤的克隆性肿瘤细胞：免疫细胞化学特征分析

Cloned neoplastic cells from a chemically-induced rat glioma: immunocytochemical characterization.

作者信息

Pilkington G J, Martin J M, Lantos P L

出版信息

Br J Exp Pathol. 1985 Oct;66(5):561-6.

PMID:2865965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2042047/
Abstract

A cell clone--A15 A5--derived from an N-ethyl-N-nitrosourea (ENU)-induced glioma in a BDIX rat has been maintained in vitro for over 50 passages. These cells, which produce tumours when injected intracerebrally into syngeneic rats, possess several features of neoplastic astrocytes. In the present study A15 A5 cells were found to express both glial fibrillary acidic protein and glutamine synthetase, thus confirming their astrocytic nature.

摘要

从一只BDIX大鼠经N-乙基-N-亚硝基脲（ENU）诱导产生的胶质瘤中分离出的细胞克隆A15 A5，已在体外传代培养50多次。将这些细胞脑内注射到同基因大鼠体内时会产生肿瘤，它们具有肿瘤性星形胶质细胞的若干特征。在本研究中，发现A15 A5细胞同时表达胶质纤维酸性蛋白和谷氨酰胺合成酶，从而证实了它们的星形胶质细胞性质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/9650e49ebe7d/brjexppathol00089-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/c73f8bc80606/brjexppathol00089-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/021c12e3854a/brjexppathol00089-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/a6a5302c19ec/brjexppathol00089-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/9650e49ebe7d/brjexppathol00089-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/c73f8bc80606/brjexppathol00089-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/021c12e3854a/brjexppathol00089-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/a6a5302c19ec/brjexppathol00089-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0d/2042047/9650e49ebe7d/brjexppathol00089-0055-a.jpg

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Cloned neoplastic cells from a chemically-induced rat glioma: immunocytochemical characterization.来自化学诱导大鼠胶质瘤的克隆性肿瘤细胞：免疫细胞化学特征分析
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Establishment of highly enriched type-2 astrocyte cultures and quantitative determination of intense glutamine synthetase activity in these cells.
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引用本文的文献

1
The effects of interferon on glial cells.干扰素对神经胶质细胞的作用。
Br J Exp Pathol. 1987 Oct;68(5):643-53.

本文引用的文献

1
Isolation of intermediate filaments from rat astrocytes in culture.从培养的大鼠星形胶质细胞中分离中间丝。
Neurosci Lett. 1981 Sep 1;25(2):119-24. doi: 10.1016/0304-3940(81)90318-9.
2
Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas.纤连蛋白和胶质纤维酸性蛋白在正常人类大脑和间变性人类胶质瘤中的表达
Cancer Res. 1982 Jan;42(1):168-77.
3
Mutually exclusive expression of fibronectin and glial fibrillary acidic protein in cultured brain cells.
Exp Cell Res. 1980 Oct;129(2):337-44. doi: 10.1016/0014-4827(80)90501-7.
4
Cell lines (VMDk) derived from a spontaneous murine astrocytoma. Morphological and immunocytochemical characterization.源自自发性小鼠星形细胞瘤的细胞系（VMDk）。形态学和免疫细胞化学特征。
J Neurol Sci. 1983 Dec;62(1-3):115-39. doi: 10.1016/0022-510x(83)90193-4.
5
The role of glutamine synthetase in the diagnosis of cerebral tumours.谷氨酰胺合成酶在脑肿瘤诊断中的作用。
Neuropathol Appl Neurobiol. 1982 May-Jun;8(3):227-36. doi: 10.1111/j.1365-2990.1982.tb00277.x.
6
Studies of the morphology and tumorigenicity of experimental brain tumours in tissue culture.组织培养中实验性脑肿瘤的形态学与致瘤性研究。
Br J Exp Pathol. 1976 Feb;57(1):95-104.
7
A common cell-type specific surface antigen in cultured human glial cells and fibroblasts: loss in malignant cells.培养的人神经胶质细胞和成纤维细胞中一种常见的细胞类型特异性表面抗原：在恶性细胞中缺失。
J Exp Med. 1976 Jan 1;143(1):64-72. doi: 10.1084/jem.143.1.64.
8
High molecular weight, cell surface-associated glycoprotein (fibronectin) lost in malignant transformation.
Biochim Biophys Acta. 1978 Sep 18;516(1):1-25. doi: 10.1016/0304-419x(78)90002-1.