McKim R H, Calverly D G, Dewhurst W G, Baker G B
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):783-6. doi: 10.1016/0278-5846(83)90066-0.
The effects of tranylcypromine (TCP) HCl (4 mg/kg and 20 mg/kg i.p.) and phenelzine (PLZ) sulfate (10 mg/kg and 50 mg/kg) on levels of dopamine (DA), noradrenaline (NA), 5-hydroxytryptamine (5-HT), 3-methoxytyramine (3-MT) and normetanephrine (NM) in mesencephalon-pons, diencephalon, corpus striatum and hippocampus of rat brain were investigated. Effects of TCP on concentrations of DA and NA varied, depending on the brain area investigated and the dosage used. PLZ either had no effect or increased the concentration of DA and NA in the areas studied. Both drugs increased the concentrations of 3-MT and NM in areas where those metabolites could be measured. Both MAO inhibitors resulted in significant increases in 5-HT in all areas studied.
研究了盐酸反苯环丙胺（TCP）（4毫克/千克和20毫克/千克腹腔注射）和硫酸苯乙肼（PLZ）（10毫克/千克和50毫克/千克）对大鼠脑的中脑-脑桥、间脑、纹状体和海马中多巴胺（DA）、去甲肾上腺素（NA）、5-羟色胺（5-HT）、3-甲氧基酪胺（3-MT）和去甲变肾上腺素（NM）水平的影响。TCP对DA和NA浓度的影响各不相同，这取决于所研究的脑区和所用剂量。PLZ要么没有影响，要么增加了所研究区域中DA和NA的浓度。两种药物都增加了可测量这些代谢物的区域中3-MT和NM的浓度。两种单胺氧化酶抑制剂均导致所有研究区域中5-HT显著增加。
