Bogaert M G, Rosseel M T
Z Kardiol. 1983;72 Suppl 3:11-3.
After oral administration of isosorbide dinitrate, plasma concentrations of isosorbide dinitrate and mononitrates can be measured. An attempt was made to identify a number of factors which influence these plasma concentrations. Presence of renal failure, acute or chronic treatment with beta-blocking agents, and chronic cimetidine treatment did not influence the plasma concentrations. In a number of patients with cirrhosis, however, plasma concentrations of isosorbide dinitrate were found to be higher than in noncirrhotic patients.
口服硝酸异山梨酯后，可测量硝酸异山梨酯和单硝酸酯的血浆浓度。人们试图确定一些影响这些血浆浓度的因素。肾衰竭的存在、β受体阻滞剂的急性或慢性治疗以及西咪替丁的慢性治疗均不影响血浆浓度。然而，在一些肝硬化患者中，发现硝酸异山梨酯的血浆浓度高于非肝硬化患者。
