Bogaert M G, Rosseel M T, Elewaut A
Int J Clin Pharmacol Ther Toxicol. 1984 Sep;22(9):491-2.
In 5 out of 7 patients with cirrhosis and extensive shunting, plasma concentrations of isosorbide dinitrate after oral administration of 10 mg of the substance were markedly higher than those found in subjects without hepatic disease. The explanation could be a higher bioavailability and/or a lower systemic clearance, due to shunting and hepatic cell dysfunction. The difference was confirmed by the calculation of the areas under the concentration-time curves.
在7例患有肝硬化且存在广泛分流的患者中，有5例在口服10毫克硝酸异山梨酯后，其血浆浓度显著高于无肝脏疾病的受试者。原因可能是由于分流和肝细胞功能障碍导致生物利用度较高和/或全身清除率较低。通过计算浓度-时间曲线下的面积证实了这种差异。
