泮库溴铵和维库溴铵后的血浆胆碱酯酶水平。

Plasma cholinesterase levels following pancuronium and vecuronium.

作者信息

Mirakhur R K, Ferres C J, Lavery T D

出版信息

Acta Anaesthesiol Scand. 1983 Dec;27(6):451-3. doi: 10.1111/j.1399-6576.1983.tb01985.x.

DOI:10.1111/j.1399-6576.1983.tb01985.x

Abstract

Plasma cholinesterase levels were measured in 52 patients following administration of pancuronium 1 mg/70 kg (10 patients) and 0.1 mg/kg (10 patients) and vecuronium in doses of 1 mg/70 kg (10 patients), 0.1 mg/kg (10 patients) and 0.2 mg/kg (12 patients). Both doses of pancuronium produced a significant (P less than 0.05 - less than 0.005) reduction in the enzyme levels. Vecuronium in a dose of 1 mg/70 kg was without any significant effects but the two higher doses produced a dose-related reduction of about 8 and 16% in the enzyme levels, respectively, which was statistically significant (P less than 0.05 - less than 0.001).

摘要

对52例患者进行了血浆胆碱酯酶水平测定，这些患者分别接受了以下药物：泮库溴铵1mg/70kg（10例患者）、0.1mg/kg（10例患者），以及维库溴铵，剂量分别为1mg/70kg（10例患者）、0.1mg/kg（10例患者）和0.2mg/kg（12例患者）。两种剂量的泮库溴铵均使酶水平显著降低（P<0.05 - <0.005）。1mg/70kg剂量的维库溴铵无显著影响，但两个较高剂量分别使酶水平降低约8%和16%，呈剂量相关性，具有统计学意义（P<0.05 - <0.001）。