Von Voigtlander P F, Puech A J
Arch Int Pharmacodyn Ther. 1983 Nov;266(1):60-76.
U-43,465F displays activity in a number of classical antidepressant assays in rodents. Mechanistically, it potentiates norepinephrine and blocks the uptake of this amine but not that of serotonin. It is not a monoamine oxidase inhibitor nor does it markedly enhance monamine release. In several behavioral assays based upon conditioned and non-conditioned behavioral suppression, U-43,465F displays anxiolytic properties. Thus this compound possesses both antidepressant-like and anxiolytic activities and may have a special utility in the treatment of depressive disorders.
U - 43,465F在啮齿动物的多种经典抗抑郁试验中表现出活性。从机制上讲，它增强去甲肾上腺素并阻断这种胺类的摄取，但不阻断血清素的摄取。它不是单胺氧化酶抑制剂，也不会显著增强单胺释放。在基于条件性和非条件性行为抑制的几种行为试验中，U - 43,465F表现出抗焦虑特性。因此，这种化合物具有抗抑郁样和抗焦虑活性，可能在抑郁症治疗中具有特殊用途。
