Castor C W
J Rheumatol Suppl. 1983 Dec;11:55-60.
Current evidence from in vitro studies draws attention to families of molecules able to stimulate replication of different classes of connective tissue cells and to stimulate the formation of some or all of the components of the extracellular matrix for which such cells are responsible. Some mediators are known to stimulate synthesis and release of enzymes with potential for degradation of the connective tissue matrix. A few of these mediators have been purified sufficiently to permit chemical characterization and immunologic measurement in man.
目前来自体外研究的证据将人们的注意力引向了一些分子家族，这些分子能够刺激不同类型的结缔组织细胞进行复制，并刺激这些细胞所负责的细胞外基质的部分或全部成分的形成。已知一些介质能刺激具有降解结缔组织基质潜力的酶的合成与释放。其中一些介质已被充分纯化，以便进行化学表征和在人体中的免疫测定。
