Lindner J, Schütte B
Hautarzt. 1976 May;27(5):214-25.
The clinical theoretical findings on skin connective tissue during the three periods of life result in new aspects of reaction possibilities of the skin under physiological and pathological conditions. The level of replication and production metabolism of skin connective tissue is high during development, maturation and ageing. Proteoglycans or glycosaminoglycans and collagen of skin connective tissue show remarkable turnover rates, during the three life periods, aging included. The interactions between these structure macromolecules and their microheterogeneity are regarded, beside elastin and denaturated collagen and their relationships. Finally the synthesis of proteoglycans and glycosaminoglycans and of collagen as well as the several influences on the several synthesis steps are shown. Therewith we receive new aspects for the therapy of skin diseases.
关于皮肤结缔组织在生命三个阶段的临床理论研究结果，揭示了皮肤在生理和病理条件下反应可能性的新方面。在发育、成熟和衰老过程中，皮肤结缔组织的复制和生产代谢水平较高。皮肤结缔组织中的蛋白聚糖或糖胺聚糖以及胶原蛋白在包括衰老在内的三个生命阶段都呈现出显著的周转率。除了弹性蛋白、变性胶原蛋白及其相互关系外，这些结构大分子之间的相互作用及其微观异质性也受到关注。最后展示了蛋白聚糖、糖胺聚糖和胶原蛋白的合成以及对各个合成步骤的多种影响。由此，我们获得了皮肤病治疗的新视角。
