Carr D H, Brown J, Bydder G M, Weinmann H J, Speck U, Thomas D J, Young I R
Lancet. 1984 Mar 3;1(8375):484-6. doi: 10.1016/s0140-6736(84)92852-6.
NMR imaging was performed on 12 patients with cerebral tumour before and after administration of intravenous gadolinium diethylene triamine penta-acetic acid (DTPA) (0.1 mmol/kg). Contrast enhancement was seen in all cases. Ring enhancement was most frequent (7 cases) but central, linear, patchy, and diffuse enhancement were also seen with both inversion-recovery and spin-echo sequences. The degree of enhancement was greater than that seen with X-ray computed tomography (CT) in 8 cases, equal to it in 3 cases, and less in 1 case. NMR distinguished between tumour and peritumoral oedema to the same extent as did CT. No side-effects were encountered and there was no significant change in urea, creatinine and electrolytes, liver function tests, blood coagulation, or urine testing after administration of gadolinium-DTPA. Gadolinium-DTPA is likely to be of considerable value in NMR imaging of the brain.
对12例脑肿瘤患者在静脉注射钆二乙三胺五乙酸（DTPA）（0.1 mmol/kg）前后进行了核磁共振成像（NMR）检查。所有病例均可见对比增强。环状增强最为常见（7例），但反转恢复序列和自旋回波序列均可见中央、线性、斑片状和弥漫性增强。增强程度在8例中大于X线计算机断层扫描（CT）所见，3例与之相等，1例小于CT所见。NMR区分肿瘤和瘤周水肿的程度与CT相同。未发现副作用，注射钆-DTPA后尿素、肌酐、电解质、肝功能检查、凝血或尿液检查均无显著变化。钆-DTPA在脑部NMR成像中可能具有相当大的价值。
