Howells R E, Devaney E, Smith G, Hedges T
Acta Trop. 1983 Dec;40(4):341-50.
The susceptibility of several strains of inbred mice to infection with the filarial worm Brugia pahangi has been examined. BALB/C, C57BL/10, C3H/He, 101, CBA/Ca mice, congenitally asplenic (DH/+) mice and their normal litter-mates (+/+) were each challenged by the intraperitoneal inoculation of 50 infective larvae. During the first four weeks of infection high (19-42%) larval recoveries were obtained from the CBA/Ca, BALB/C and Dh/+ mice but fewer than 10% of inoculated larvae were recovered from C3H/He, 101; C57BL/10 and +/+ mice. Larval growth rates in all mice were similar. BALB/C and Dh/+ mice only were examined later than four weeks after infection. The yield of adult worms from BALB/C was 7.5% at 16 weeks and from Dh/+ 4.2% at 21 weeks. Microfilariae were present in the peritoneal fluids but not the blood of some mice harbouring both adult male and female worms.
已对几种近交系小鼠感染丝虫布氏彭亨丝虫的易感性进行了研究。将BALB/C、C57BL/10、C3H/He、101、CBA/Ca小鼠、先天性无脾（DH/+）小鼠及其正常同窝仔鼠（+/+）每组通过腹腔接种50条感染性幼虫进行攻毒。在感染的前四周，从CBA/Ca、BALB/C和Dh/+小鼠中获得了较高的（19 - 42%）幼虫回收率，但从C3H/He、101、C57BL/10和+/+小鼠中回收的接种幼虫不到10%。所有小鼠的幼虫生长率相似。仅对BALB/C和Dh/+小鼠在感染四周后进行了检查。BALB/C小鼠在16周时成虫产出率为7.5%，Dh/+小鼠在21周时为4.2%。在一些同时含有成年雄虫和雌虫的小鼠的腹腔液中存在微丝蚴，但血液中没有。
