Day J F, Edman J D
Comp Biochem Physiol A Comp Physiol. 1984;77(3):447-52. doi: 10.1016/0300-9629(84)90210-x.
Laboratory mice infected with rodent malaria (Plasmodium berghei or P. chabaudi) or St. Louis encephalitis virus (SLE) were not hyperthermic during the infection period. However, all infected animals displayed pathogen-specific periods of hypothermia. Hamsters infected with P. berghei were hyperthermic on day 7 postinfection (PI) but became hypothermic on day 8 PI and remained so until death, approximately 20 days PI. Body temperatures of mice infected with P. yoelii were not significantly different from those of uninfected control mice. Mosquitoes (Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus) successfully engorged on restrained, uninfected mice, but were unable to engorge on unrestrained, uninfected mice due to the natural antimosquito behavior of the healthy rodents. Mosquitoes successfully engorged on unrestrained, malaria or SLE infected mice only during certain pathogen-specific periods of infection, but were able to engorge on all restrained, infected mice throughout the infection period regardless of the animal's body temperature. Daily activity patterns of malaria infected mice followed pathogen-specific profiles which closely conformed to the observed mosquito-engorgement profiles.
感染啮齿类疟疾（伯氏疟原虫或查巴迪疟原虫）或圣路易斯脑炎病毒（SLE）的实验小鼠在感染期间并未出现体温过高的情况。然而，所有受感染动物都出现了病原体特异性的体温过低期。感染伯氏疟原虫的仓鼠在感染后第7天体温过高，但在感染后第8天体温开始降低，并一直持续到死亡，大约在感染后20天。感染约氏疟原虫的小鼠体温与未感染的对照小鼠相比没有显著差异。蚊子（埃及伊蚊、斯氏按蚊和致倦库蚊）能够成功叮咬被束缚的未感染小鼠，但由于健康啮齿动物天然的防蚊行为，无法叮咬未被束缚的未感染小鼠。蚊子仅在感染的特定病原体特异性时期能够成功叮咬未被束缚的感染疟疾或SLE的小鼠，但在整个感染期间，无论动物体温如何，都能够叮咬所有被束缚的感染小鼠。感染疟疾的小鼠的日常活动模式遵循病原体特异性模式，这与观察到的蚊子叮咬模式密切相符。
