Claiborne B J, Selverston A I
J Neurosci. 1984 Mar;4(3):708-21. doi: 10.1523/JNEUROSCI.04-03-00708.1984.
Histamine is a putative neurotransmitter in mammals and molluscs, but its role in the nervous systems of other animals is not known. This study examines the possibility that histamine is a neurotransmitter in an arthropod. Results show that first, 14 neurons in the stomatogastric ganglion of the spiny lobster respond to histamine. The response is inhibitory, is mediated by an increased conductance to chloride, and desensitizes with repeated applications of histamine. These same 14 neurons receive one type of synaptic potential from two extrinsic neurons, the "through-fibers" of the inferior ventricular nerve. This synaptic potential is also inhibitory, is mediated by an increased conductance to chloride, and is blocked when histamine receptors are desensitized. Second, assays of endogenous histamine indicate that histamine is distributed nonuniformly throughout the stomatogastric nervous system and that its distribution correlates with the axonal pathways and terminal arborizations of the inferior ventricular nerve through-fibers. Lastly, histamine is present in relatively high concentrations in the cell bodies of the through-fibers, whereas it is not detectable in other neurons in the stomatogastric system. These results suggest that histamine may be a transmitter in the lobster.
组胺在哺乳动物和软体动物中被认为是一种神经递质，但它在其他动物神经系统中的作用尚不清楚。本研究探讨了组胺是否为节肢动物神经递质的可能性。结果表明，首先，多刺龙虾口胃神经节中的14个神经元对组胺有反应。该反应具有抑制性，由氯离子电导增加介导，并在反复应用组胺后脱敏。同样的这14个神经元从两个外在神经元，即下脑室神经的“贯穿纤维”接收一种突触电位。这种突触电位也是抑制性的，由氯离子电导增加介导，并且在组胺受体脱敏时被阻断。其次，内源性组胺检测表明，组胺在整个口胃神经系统中分布不均匀，其分布与下脑室神经贯穿纤维的轴突通路和终末分支相关。最后，组胺在贯穿纤维的细胞体中浓度相对较高，而在口胃系统的其他神经元中则检测不到。这些结果表明组胺可能是龙虾中的一种递质。
