Wong C G, Meyer R B
J Med Chem. 1984 Apr;27(4):429-32. doi: 10.1021/jm00370a003.
A series of 2-substituted inosine monophosphate (IMP) and inosine derivatives were synthesized and tested for inhibitory activity against IMP dehydrogenase from Escherichia coli. All of the IMP analogues that possessed electron-withdrawing substituents on the phenyl ring of a benzylthio group placed at the 2-position of IMP showed strong inhibition, which was competitive with IMP. No evidence of hydrophobic interactions of the 2-substituent with the enzyme was observed.
合成了一系列2-取代的肌苷一磷酸（IMP）和肌苷衍生物，并测试了它们对大肠杆菌IMP脱氢酶的抑制活性。所有在IMP 2位的苄硫基苯环上带有吸电子取代基的IMP类似物均表现出强烈的抑制作用，且与IMP具有竞争性。未观察到2-取代基与该酶存在疏水相互作用的证据。
