Wiseman G M, Martin C F, McNicol P J
Can J Microbiol. 1984 Jan;30(1):52-6. doi: 10.1139/m84-009.
Pilated gonococci added to human erythrocytes apparently bind to polypeptide band 3 and inhibit chloride-bicarbonate exchange across the membrane in contrast with nonpilated organisms. Known covalent inhibitors of anion transport (4,4'-diisothiocyano-2,2'-disulphonic acid stilbene and alpha-cyano-4-hydroxycinnamic acid) inhibit chloride efflux from erythrocytes and also reduce hemagglutination titres, strongly suggesting that band 3 is the major host-cell receptor involved in all interaction between gonococci and erythrocytes. In studies of other cell species, however, band 3 prepared from human erythrocytes inhibited adherence of pilated gonococci to human foreskin and HeLa cells, but was without effect in human buccal, Vero, and mouse L cells.
与非菌毛淋病奈瑟菌相比，添加到人类红细胞中的菌毛淋病奈瑟菌显然与带3多肽结合，并抑制跨膜氯-碳酸氢根交换。已知的阴离子转运共价抑制剂（4,4'-二异硫氰酸-2,2'-二磺酸芪和α-氰基-4-羟基肉桂酸）抑制红细胞中的氯外流，也降低血凝滴度，强烈表明带3是淋病奈瑟菌与红细胞之间所有相互作用中涉及的主要宿主细胞受体。然而，在对其他细胞种类的研究中，从人类红细胞制备的带3抑制菌毛淋病奈瑟菌对人包皮和HeLa细胞的黏附，但对人颊细胞、非洲绿猴肾细胞和小鼠L细胞无效。
