Dencker S J
J Clin Psychiatry. 1984 May;45(5 Pt 2):22-7.
The three developmental phases in the acceptance and use of depot neuroleptics are described. The practical advantages of these drugs are considered, as well as the extrapyramidal side effects that may result from oral or depot administration. Local (injection site) and other side effects of depot neuroleptics are discussed. Typical plasma drug concentration curves and receptor responses of depot neuroleptics are illustrated. Alternative use of oral drugs and strategies to increase the effectiveness of depot forms are presented. The depot neuroleptics used in Scandinavia today are discussed, and predictions are made regarding their use in the future.
描述了长效抗精神病药物接受和使用的三个发展阶段。考虑了这些药物的实际优势，以及口服或长效给药可能产生的锥体外系副作用。讨论了长效抗精神病药物的局部（注射部位）和其他副作用。说明了长效抗精神病药物的典型血浆药物浓度曲线和受体反应。介绍了口服药物的替代使用方法以及提高长效剂型有效性的策略。讨论了当今斯堪的纳维亚使用的长效抗精神病药物，并对其未来的使用进行了预测。
