Kane J M
J Clin Psychiatry. 1984 May;45(5 Pt 2):5-12.
The use of long-acting injectable preparations such as fluphenazine enanthate or decanoate can reduce patient noncompliance, but documenting this in a controlled research design is difficult. Several studies of relapse rates among patients receiving oral fluphenazine, depot fluphenazine, or placebo are reviewed. Factors that may explain the lack of significant differences among different drug treatments in preventing relapse are discussed. Indications are presented for the use of depot neuroleptics, and strategies for achieving minimum effective doses are reviewed. Adverse effects of depot medication are also discussed, so that the clinician may maximize the ratio of benefit to risk.
使用氟奋乃静庚酸酯或癸酸酯等长效注射制剂可减少患者不依从性，但在对照研究设计中记录这一点很困难。本文综述了几项关于接受口服氟奋乃静、长效氟奋乃静或安慰剂的患者复发率的研究。讨论了不同药物治疗在预防复发方面缺乏显著差异的可能原因。介绍了长效抗精神病药物的使用指征，并综述了实现最小有效剂量的策略。还讨论了长效药物的不良反应，以便临床医生能够最大化效益风险比。
