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苯二氮䓬受体拮抗剂可逆转地西泮对应激大鼠血浆皮质酮的作用。

Benzodiazepine receptor antagonists reverse the effect of diazepam on plasma corticosterone in stressed rats.

作者信息

Bizzi A, Ricci M R, Veneroni E, Amato M, Garattini S

出版信息

J Pharm Pharmacol. 1984 Feb;36(2):134-5. doi: 10.1111/j.2042-7158.1984.tb03014.x.

DOI:10.1111/j.2042-7158.1984.tb03014.x
PMID:6143804
Abstract

The aim of this work has been to investigate the mechanism by which diazepam counteracts the plasma corticosterone rise induced by stress in rats. This effect is reversed by pretreatment with RO151788 and CGS8216. This observation suggests that the effect is mediated by benzodiazepine-specific receptors in brain.

摘要

这项工作的目的是研究地西泮抵消应激诱导的大鼠血浆皮质酮升高的机制。用RO151788和CGS8216预处理可逆转这种效应。这一观察结果表明，该效应是由脑中的苯二氮䓬特异性受体介导的。

相似文献

1
Benzodiazepine receptor antagonists reverse the effect of diazepam on plasma corticosterone in stressed rats.苯二氮䓬受体拮抗剂可逆转地西泮对应激大鼠血浆皮质酮的作用。
J Pharm Pharmacol. 1984 Feb;36(2):134-5. doi: 10.1111/j.2042-7158.1984.tb03014.x.
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The neuropharmacology of various diazepam antagonists.
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Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors.苯二氮䓬受体选择性拮抗剂可逆转地西泮的抗厌恶和抗惊厥作用，但不能逆转普罗加比的此类作用。
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Benzodiazepine receptor ligands with opposing pharmacologic actions.具有相反药理作用的苯二氮䓬受体配体。
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Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.使用Ro 15 - 1788对体内苯二氮䓬受体进行研究：褪黑素的抗惊厥和镇静作用以及苯二氮䓬Ro 05 - 3663的惊厥作用的研究。
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The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response.假定的致焦虑化合物（FG 7142、CGS 8216和Ro 15-1788）对大鼠皮质酮反应的影响。
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Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.苯二氮䓬受体拮抗剂Ro 15 - 1788的内在作用。
Psychopharmacology (Berl). 1986;88(1):1-11. doi: 10.1007/BF00310505.
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Comparison of the effects of chlordiazepoxide and CL 218,872 on serum corticosterone concentrations in rats.氯氮卓与CL 218,872对大鼠血清皮质酮浓度影响的比较。
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