Pellow S, File S E
Physiol Behav. 1985 Oct;35(4):587-90. doi: 10.1016/0031-9384(85)90145-3.
The effects of FG 7142, CGS 8216 and Ro 15-1788, three compounds that are believed to produce anxiety by an action at benzodiazepine receptors in the CNS, are investigated on the plasma corticosterone concentrations in the rat both in the home cage and after exposure to novelty stress. FG 7142 (5 mg/kg) and CGS 8216 (10 mg/kg), but not Ro 15-1788 (4 or 10 mg/kg) increased basal corticosterone levels in the home cage, and all three compounds potentiated the increase in corticosterone concentrations observed after exposure to a novel environment. The relationship between the effects of drugs on corticosterone concentrations and on anxiety is considered in the light of these results.
研究了FG 7142、CGS 8216和Ro 15 - 1788这三种被认为通过作用于中枢神经系统苯二氮䓬受体而产生焦虑的化合物，对大鼠在饲养笼中以及暴露于新异应激后的血浆皮质酮浓度的影响。FG 7142（5毫克/千克）和CGS 8216（10毫克/千克），但不是Ro 15 - 1788（4或10毫克/千克）增加了饲养笼中的基础皮质酮水平，并且所有三种化合物都增强了暴露于新环境后观察到的皮质酮浓度的增加。根据这些结果，考虑了药物对皮质酮浓度和焦虑的影响之间的关系。
