Kasurinen J, Syrjänen K J
Scand J Gastroenterol. 1984 Mar;19(2):167-72.
A series of 25 apudomas of the gastrointestinal tract (22 cases), bronchus (2 cases), and thymus (1 case) were subjected to staining with silver impregnation (Masson-Fontana and Grimelius) techniques and with the commercial immunoperoxidase kits for the peptide hormones adrenocorticotropin, calcitonin, gastrin, glucagon, growth hormone, human chorionic gonadotropin (hCG), insulin, somatostatin, and vasoactive intestinal peptide. Of the tumors studied, 16 were regarded as malignant, and 5 of the patients showed clinical symptoms due to inappropriate hormone secretion. A total of 16 tumors contained cells positive for 1 or more (6 were multihormonal) of the hormones studied. One bronchial carcinoid stained for hCG, which has not been previously reported. In addition, one of the rectal carcinoids contained somatostatin-positive cells, only once described previously. The thymic tumor proved frankly malignant, most probably identical to the oat-cell carcinoma recently described. The findings also substantiate the recent suggestion that gastrointestinal carcinoids cannot be adequately classified on the basis of silver stains only and strongly advocate the use of the immunoperoxidase kits in routine assessments of all the endocrinologically active tumors, whatever their localization might be.
对一系列25例胃肠道（22例）、支气管（2例）和胸腺（1例）的APUD瘤进行了银浸染（马松 - 丰塔纳法和格里梅利乌斯法）技术染色，并使用商业免疫过氧化物酶试剂盒检测肽类激素促肾上腺皮质激素、降钙素、胃泌素、胰高血糖素、生长激素、人绒毛膜促性腺激素（hCG）、胰岛素、生长抑素和血管活性肠肽。在所研究的肿瘤中，16例被视为恶性，5例患者因激素分泌异常出现临床症状。共有16个肿瘤含有对所研究的1种或多种（6个为多激素性）激素呈阳性的细胞。1例支气管类癌对hCG染色阳性，此前未见报道。此外，1例直肠类癌含有生长抑素阳性细胞，此前仅被描述过一次。胸腺肿瘤被证实为明显恶性，很可能与最近描述的燕麦细胞癌相同。这些发现也证实了最近的观点，即仅根据银染不能对胃肠道类癌进行充分分类，并强烈主张在对所有内分泌活性肿瘤进行常规评估时使用免疫过氧化物酶试剂盒，无论其定位如何。
