al-Saffar N, White A, Moore M, Hasleton P S
Department of Pathology, Wythenshawe Hospital, Manchester, UK.
Br J Cancer. 1988 Dec;58(6):762-6. doi: 10.1038/bjc.1988.304.
The presence of a number of regulatory peptides (bombesin, gastrin, glucagon, somatostatin, calcitonin and ACTH) was compared in 30 typical carcinoid tumours and 27 well differentiated neuroendocrine carcinomas (atypical carcinoids) using conventional immunocytochemistry. Strong immunostaining for one or more peptide was observed in 97% of the typical carcinoids (29/30) whereas only 67% of the neuroendocrine carcinomas showed immunoreactivity. The peptide most frequently detected in typical carcinoids was bombesin (67%), while gastrin was more common in neuroendocrine carcinomas (44%). Immunoreactivity for more than one peptide was present in 33 tumours and in three cases, six different peptides were detected. The study shows that immunoreactivity to various peptides is more common in typical carcinoids than well differentiated neuroendocrine carcinomas. The significance of these findings is discussed.
采用传统免疫细胞化学方法，对30例典型类癌肿瘤和27例高分化神经内分泌癌（非典型类癌）中多种调节肽（蛙皮素、胃泌素、胰高血糖素、生长抑素、降钙素和促肾上腺皮质激素）的存在情况进行了比较。在97%的典型类癌（29/30）中观察到一种或多种肽的强免疫染色，而只有67%的神经内分泌癌显示出免疫反应性。在典型类癌中最常检测到的肽是蛙皮素（67%），而胃泌素在神经内分泌癌中更为常见（44%）。33个肿瘤中存在对一种以上肽的免疫反应性，在3例中检测到6种不同的肽。该研究表明，典型类癌中对各种肽的免疫反应性比高分化神经内分泌癌更常见。讨论了这些发现的意义。
