海葵毒素（ATX-II）对大鼠神经肌肉接头微小终板电位频率的影响。
Effects of sea-anemone toxin (ATX-II) on the frequency of miniature endplate potentials at rat neuromuscular junctions.
作者信息
Harris J B, Tesseraux I
出版信息
Br J Pharmacol. 1984 Apr;81(4):573-4. doi: 10.1111/j.1476-5381.1984.tb16120.x.
Abstract
Soleus and extensor digitorum longus muscles were isolated from rats. The muscles were exposed to ATX-II, a toxin isolated from extracts of the sea-anemone Anemonia sulcata . The toxin caused a dose-dependent increase in the frequency of miniature endplate potentials in both types of muscle. The increase in frequency could be reversed by the application of tetrodotoxin (TTX), and could be prevented by prior exposure of the muscles to TTX. It is concluded that ATX-II causes a sodium-dependent depolarization of the nerve-terminal membrane.
摘要
从大鼠身上分离出比目鱼肌和趾长伸肌。将这些肌肉暴露于从海葵沟迎风海葵提取物中分离出的毒素ATX-II中。该毒素使两种类型的肌肉中微小终板电位的频率呈剂量依赖性增加。频率的增加可通过应用河豚毒素（TTX）来逆转，并且可以通过预先将肌肉暴露于TTX来预防。得出的结论是，ATX-II导致神经末梢膜的钠依赖性去极化。
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