McGeer E G, McGeer P L
Brain Res. 1984 Apr 30;298(2):339-42. doi: 10.1016/0006-8993(84)91433-1.
Injections of kainic acid into the rostral pontine tegmentum in rats caused not only local lesions but destruction of GABAergic and dopaminergic cells in the substantia nigra (SN), as indicated histologically and by measurements of tyrosine hydroxylase (TH) and glutamate decarboxylase (GAD). Injections of folic acid caused the nigral damage without local lesions. Pretreatment with scopolamine prevented the losses in GAD without affecting those in TH. The destruction of nigral cells is attributed to pathological stimulation of afferent pathways to the SN, some of which are cholinergic, and it is possible that a similar mechanism may be involved in some forms of Parkinsonism.
向大鼠脑桥被盖前部注射海藻酸不仅会导致局部损伤，还会引起黑质中γ-氨基丁酸能（GABAergic）和多巴胺能细胞的破坏，这在组织学上以及通过酪氨酸羟化酶（TH）和谷氨酸脱羧酶（GAD）的测量得到了证实。注射叶酸会导致黑质损伤但无局部损伤。用东莨菪碱预处理可防止GAD的损失，而不影响TH的损失。黑质细胞的破坏归因于对黑质传入通路的病理刺激，其中一些是胆碱能的，并且在某些形式的帕金森病中可能涉及类似的机制。
