精神分裂症患者黑质中的多巴胺D2受体
Dopamine D2 receptors in substantia nigra in schizophrenia.
作者信息
Owen R, Owen F, Poulter M, Crow T J
出版信息
Brain Res. 1984 May 7;299(1):152-4. doi: 10.1016/0006-8993(84)90798-4.
PMID:6144367
Abstract
Dopamine D2 receptors were assessed in samples of substantia nigra from controls and schizophrenics. Specific [3H]spiperone binding was significantly increased in both neuroleptic-free and neuroleptic-treated schizophrenics. This supports our previous suggestion that the increase in D2 receptors observed in striatum of schizophrenics is not wholly due to neuroleptic medication.
摘要
在对照组和精神分裂症患者的黑质样本中评估了多巴胺D2受体。在未服用抗精神病药物和服用抗精神病药物治疗的精神分裂症患者中，特异性[3H]螺哌隆结合均显著增加。这支持了我们之前的观点，即精神分裂症患者纹状体中观察到的D2受体增加并非完全归因于抗精神病药物治疗。
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