Gola M, Ducreux C
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(2):257-66. doi: 10.1016/0742-8413(84)90010-0.
The effects of strychnine on Aplysia R2 neurons were evaluated using simultaneous intracellular recordings of the soma and axon potentials. 1 mM strychnine produced a slight enlargement of the somatic spike and a large increase of the axon spike duration. Following direct stimulation, the soma displayed depolarizing afterpotentials ( DAPs ) which might trigger extra-spikes, both produced electronically by long-lasting axon spikes. Cobalt suppressed both the axon spike lengthening and the somatic extra-spikes or DAPs , and induced large depolarizing shifts in the soma. The region of largest spike lengthening (proximal axon) had a large density of Ca channels. The different effects of strychnine on the soma and on the axon were assumed to result from a selective blockage of the V-dependent K channels which would predominate in the axon whereas Ca-activated K channels would predominate in the soma.
使用对体细胞和轴突电位的同步细胞内记录来评估士的宁对海兔R2神经元的影响。1 mM士的宁使体细胞动作电位略有增大，并使轴突动作电位持续时间大幅增加。直接刺激后，体细胞显示出去极化后电位（DAPs），这可能触发额外的动作电位，两者均由持久的轴突动作电位以电方式产生。钴抑制了轴突动作电位的延长以及体细胞的额外动作电位或DAPs，并在体细胞中诱导了大的去极化偏移。动作电位延长最大的区域（近端轴突）具有高密度的钙通道。士的宁对体细胞和轴突的不同作用被认为是由于对电压依赖性钾通道的选择性阻断所致，该通道在轴突中占主导地位，而钙激活钾通道在体细胞中占主导地位。
