在存在四乙铵（TEA）的情况下，海兔轴突重复放电期间，动作电位时程的钙依赖性增加。

Calcium-dependent increase in spike duration during repetitive firing of Aplysia axon in the presence of TEA.

作者信息

Horn R, Miller J J

出版信息

J Neurobiol. 1978 Sep;9(5):341-52. doi: 10.1002/neu.480090502.

Abstract

Repetitive stimulation was studied in the axon of the giant neuron, R2, of Aplysia in the presence of TEA. In 25 or 50 mM extracellular TEA, a plateau develops on the axon spike during repetitive stimulation at frequencies greater than 3/sec. The plateau in extracellular TEA is inhibited by 30 mM CoCl2 or 1 mM CdCl2, and is enhanced by raising the Ca concentration. Intracellular TEA induces a plateau on the axon spike at frequencies less than 1/30sec. This plateau increases in duration with repetitive stimulation at higher frequencies and is inhibited by 30 mM CoCl2 or 1 mM CdCl2. The increase in spike duration during repetitive firing in the presence of TEA is indicative of an increased entry of Ca during the spike train.

摘要

在存在四乙铵（TEA）的情况下，对海兔巨大神经元R2的轴突进行了重复刺激研究。在细胞外25或50 mM TEA中，当重复刺激频率大于3次/秒时，轴突动作电位会出现一个平台期。细胞外TEA中的平台期可被30 mM氯化钴（CoCl2）或1 mM氯化镉（CdCl2）抑制，并通过提高钙离子浓度而增强。细胞内TEA在频率小于1/30秒时会在轴突动作电位上诱导出一个平台期。这个平台期在较高频率的重复刺激下持续时间增加，并被30 mM CoCl2或1 mM CdCl2抑制。在TEA存在的情况下，重复放电期间动作电位持续时间的增加表明在一串动作电位期间钙离子进入增加。