小鼠生物膜在适应乙醇过程中的流动性和脂质组成
Fluidity and lipid composition of mouse biomembranes during adaptation to ethanol.
作者信息
Chin J H, Goldstein D B, Parsons L M
出版信息
Alcohol Clin Exp Res. 1979 Jan;3(1):47-9. doi: 10.1111/j.1530-0277.1979.tb04767.x.
Abstract
Showing that ethanol added in vitro increased the fluidity of mouse erythrocyte and synaptosomal membranes and that the same membranes isolated from mice after chronic treatment with ethanol had increased cholesterol and were resistant to ethanol in vitro, the study suggests that the animals had adapted to the chronic presence of the drug by changing their membrane lipid composition to offset the fluidizing effects of ethanol.
摘要
该研究表明，体外添加乙醇可增加小鼠红细胞和突触体膜的流动性，且从经乙醇长期处理的小鼠分离出的相同膜中胆固醇增加，并且在体外对乙醇具有抗性，这表明动物已通过改变其膜脂质组成来适应药物的长期存在，以抵消乙醇的流化作用。
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