Boyer P
Encephale. 1983;9(4 Suppl 2):59B-65B.
After ingestion of equal doses of a given benzodiazepine serum concentrations vary greatly from one individual to another, suggesting that it may be advisable to monitor circulating drug levels. But so far, few studies have been conducted on the relation between benzodiazepine serum concentrations and clinical results. In general, these studies conclude that there is no significant relation between circulating drug levels and anxiolytic activity. On the other hand, the kinetic properties of benzodiazepines determine the type, rapidity of onset and duration of action of each drug. Onset of action depends on the speed of absorption of the product, and duration of action depends on how widely it is diffused. After administration of repeated doses of a benzodiazepine, accumulation of the drug depends on its half-life of elimination and metabolic clearance. Finally, the side-effects of benzodiazepines are often related to their concentrations in the plasma, but in cases of massive intoxication, there is often a dissociation between drug serum levels and the clinical picture.
在摄入等量的某种苯二氮䓬类药物后，个体之间的血清浓度差异很大，这表明监测循环药物水平可能是明智的。但到目前为止，关于苯二氮䓬类药物血清浓度与临床结果之间关系的研究很少。总体而言，这些研究得出结论，循环药物水平与抗焦虑活性之间没有显著关系。另一方面，苯二氮䓬类药物的动力学特性决定了每种药物的类型、起效速度和作用持续时间。起效取决于药物的吸收速度，作用持续时间取决于其扩散范围。在重复给予苯二氮䓬类药物后，药物的蓄积取决于其消除半衰期和代谢清除率。最后，苯二氮䓬类药物的副作用通常与其血浆浓度有关，但在大量中毒的情况下，药物血清水平与临床表现之间往往存在脱节。
