McRae-Degueurce A, Sinton C M
Exp Brain Res. 1984;54(2):373-6. doi: 10.1007/BF00236239.
Variations in tyrosine hydroxylase (TH) activity and serotonin (5-HT) content in the rat locus coeruleus were measured four days after lesion of the nucleus raphe centralis superior. Lesions were made under either ether or pentobarbital anaesthesia and, in addition, (under ether) in rats pretreated with atropine or with lesions of the medial septum. Results showed a dissociation between 5-HT reduction and TH induction, differences due to the anaesthetic used, and a possible influence from limbic centres on 5-HT in the LC. These findings are discussed in terms of the apparent complexity of raphe-coerulean interactions.
在中缝背核上部受损四天后，测量大鼠蓝斑中酪氨酸羟化酶（TH）活性和5-羟色胺（5-HT）含量的变化。损伤是在乙醚或戊巴比妥麻醉下进行的，此外，（在乙醚麻醉下）还对用阿托品预处理的大鼠或内侧隔区受损的大鼠进行了实验。结果显示5-HT减少与TH诱导之间存在分离，因所用麻醉剂不同而产生差异，并且边缘系统中枢可能对蓝斑中的5-HT有影响。根据中缝-蓝斑相互作用的明显复杂性对这些发现进行了讨论。
